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MYR - TYS

$101 Find cheap flights from Myrtle Beach to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Thu 7/11
Thu 7/18

Search hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
In the last 7 days travelers have searched 44,212,782 times on KAYAK, and here is why:

Save 21% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Bundle and saveSave money when you bundle your flight + hotel.

Cheap flight deals from Myrtle Beach to Knoxville (MYR-TYS)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
2:58 pm - 11:11 pmMYR-TYS
8h 13m1 stop
8:10 am - 7:07 pmTYS-MYR
10h 57m1 stop
Thu, Jul 11 - Mon, Jul 22
2:58 pm - 11:11 pmMYR-TYS
8h 13m1 stop
10:00 am - 8:42 pmTYS-MYR
10h 42m1 stop
Thu, Jul 11 - Tue, Jul 23
2:58 pm - 11:11 pmMYR-TYS
8h 13m1 stop
10:00 am - 9:29 pmTYS-MYR
11h 29m2 stops
Thu, Jul 11 - Tue, Jul 23
8:57 am - 2:07 pmMYR-TYS
5h 10m1 stop
8:26 pm - 11:57 pmTYS-MYR
3h 31m1 stop
$218American Airlines
Find Deal
Wed, Sep 4 - Fri, Sep 6
9:44 pm - 1:00 pmMYR-TYS
15h 16m2 stops
9:00 am - 5:22 pmTYS-MYR
8h 22m1 stop
Mon, Jul 15 - Wed, Jul 31
9:55 am - 7:32 pmMYR-TYS
9h 37m1 stop
6:30 am - 5:22 pmTYS-MYR
10h 52m1 stop
Wed, Jul 10 - Thu, Jul 11
8:09 pm - 12:02 amMYR-TYS
3h 53m1 stop
5:10 am - 10:10 amTYS-MYR
5h 00m1 stop
$253American Airlines
Find Deal
Mon, Jul 15 - Wed, Jul 31
6:00 am - 11:19 amMYR-TYS
5h 19m1 stop
7:56 pm - 11:56 pmTYS-MYR
4h 00m1 stop
$393Delta
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Thu, Aug 15 - Sun, Aug 18
6:32 pm - 4:56 pmMYR-TYS
22h 24m2 stops
7:10 pm - 12:31 pmTYS-MYR
17h 21m2 stops
$544United Airlines
Find Deal
Thu, Aug 15 - Sun, Aug 18
11:10 am - 11:44 pmMYR-TYS
12h 34m2 stops
5:20 pm - 3:05 pmTYS-MYR
21h 45m2 stops
$554United Airlines
Find Deal
Wed, Sep 4 - Fri, Sep 6

Flights from Myrtle Beach to Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Myrtle Beach to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Knoxville?

The average price of all flights from Myrtle Beach to Knoxville clicked on KAYAK for each day over the last 12 months.
For Myrtle Beach to Knoxville, Tuesday is the cheapest day to fly on average and Sunday is the most expensive. Flying from Knoxville back to Myrtle Beach, the best deals are generally found on Tuesday, with Friday being the most expensive.

Good to know

High season

October

Cheapest flight

$101
Most popular time to fly and prices are also 13% lower on average.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Knoxville

  • What is the cheapest flight from Myrtle Beach to Knoxville?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Knoxville was $101 for a one-way ticket and $206 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Knoxville?

    No

  • Which aircraft models fly most regularly from Myrtle Beach to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Knoxville?

    oneworld, SkyTeam, and Star Alliance are the airline alliances operating flights between Myrtle Beach and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Myrtle Beach to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Myrtle Beach to Knoxville are Delta and American Airlines. With an average price for the route of $376 and an overall rating of 8.0, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $401 and an overall rating of 7.3.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top airlines flying from Myrtle Beach to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10277 reviews
8.6Crew
8.2Boarding
8.0Entertainment
7.4Food
7.9Comfort
Airline reviews

3 hours late and all they have is was a $12 meal voucher. That’s not even enough to cover fast food.

2.0 MediocreCraig, Jun 2024CVG - LGA
Read more about Delta reviews

3 hours late and all they have is was a $12 meal voucher. That’s not even enough to cover fast food.

Among the poorest flights I’ve had with Delta in a while. Entertainment system failed completely on a 7.5 hr flight. Crew seemed distracted and not the normal friendly crew. Flight overbooked it seemed… very crowded.

If I can, I always fly Delta. I’ve found their service to always be reliable and pleasant.

You could have not cancelled the flight (AA, which I will be flying from now on) left for BOS despite the fictitious weather issues (that no one in my Boston family could see). You could have rebooked my direct flight to another direct flight instead of sending me though JFK, the worst US airport after O’Hara You could have rebooked me on a Main Cabin seat (like the one I paid for in my original ticket instead of putting me a the last row on JFK->BOS leg, pocketing the difference in ticket price But I do not really care whether you will ever do that in a future because in a future neither I nor anyone from my company (unless they pay out of pocket) nor an of my clients and partners (if they heed my advice) will ever be caught dead on any of Delta flights

Really bad baggage handling. Had my Rimowa bag badly damaged at the latches.

It was pretty good I was worried with the short Layover that I might not catch my connection but the gate was there

It was good until there was a 3 hour delay because there was not any pilots to fly the plane.

There was plenty of overhead room but half of the passengers were told they had to check their carryon bags. My partner and I checked in as early as possible and our seats were split across the aisle.

Friendly flight attendants. Comfort plus seats were very comfortable and had lots of leg room. 10A and 10 B.

Flew first class so everything was great. But maybe because the flights were red eye, no meals were served, just chips. I flew Alaska Air 1st class at 9PM (2 hour flight) and they served beef short rib sliders!

Paid for premium economy had no tv the whole time the crew tried to reset/reboot but would not work they said they would put a trouble ticket in for it. We had 3 seats my tv was the only one that didn't work. They cancelled our flight re worked us on another that left us at airport over night on the floor I have a ten year old and a 78 diabetic mother which also had shingles and suffers from nerve pain in legs and back. Requested wheelchair service at all airports after the re route NO wheelchair service was there to help. WORST experience we have ever had. Went to American airlines assistance it was closed. I AM FURIOUS!!! I expect some sort of compensation from this traumatic experience and no need for flying points we don't plan on using American airlines again!!!!

This is by far the worst experience I have had with American Airlines. The start of this trip was a complete disaster. I purposely planned my trip so that I would weather any delays so that I could make very important meeting at the Pentagon. My flight was cancelled because of maintenance and I was put on the first flight the next day but I was late to the meeting. After a long week at the Pentagon I just wanted to go home and my flight home which was early in the day was delayed. Eventually the flight was delayed until the next day. I was not authorized a hotel room because DCA was my point of origin. So I paid for a hotel out of pocket. The flight this morning was boarded then deplaned because the aircraft was hot. The flow of information was not happening in DCA and made it worse when the news was bad. I am going to take a break from American for my next few military flights. Hopefully whatever has been going on with American Airlines will be resolved.

We had a 2 hour delay. The seats were smaller than most other airlines. The person in front of us wanted to lay back and we had to stop her because she was pressing against my girlfriend’s legs. We had to ask her to sit up and not lay back due to the lack of room.

Everything was fine once we actually got on our flight. It was more then annoying they canceled (delayed) our flight. We lost out on a day of our trip along with money on our stay. Plus we had to book another hotel. So expensive.

This flight was canceled and delayed several times without explanation. The plane was freezing cold and no wifi for messaging. Getting off the plane was terribly unorganized and felt like it took forever….

The flight was delayed several times without explanation. The seats were terribly uncomfortable and wifi isn’t included. All these make for a less than ideal flight.

The flights was delayed by hours and it was the firmest landing I have experienced in my life. My back is still sore.

Internet service was erratic. Crew service was poor and slow. My luggage on this non-stop flight was lost and not recovered

Terrible. I didn’t fly and I had an important meeting the next day.

Equipment swap led to 2+ hour delay on international flight. And to top it off, boarding took forever.

Book cheap flights from Myrtle Beach to Knoxville

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Myrtle Beach to Knoxville found on KAYAK in the last 72 hours.
9/26Thu
1 stop
7h 02mMYR-TYS
$101
6/19Wed
1 stop
14h 57mMYR-TYS
$111
9/26Thu
2 stops
16h 24mMYR-TYS
$123
7/12Fri
1 stop
15h 25mMYR-TYS
$130
9/26Thu
3 stops
15h 44mMYR-TYS
$133
6/19Wed
2 stops
17h 14mMYR-TYS
$149
7/12Fri
2 stops
7h 47mMYR-TYS
$167
7/12Fri
3 stops
27h 25mMYR-TYS
$196
7/31Wed
1 stopAmerican Airlines
10h 52mMYR-TYS
$240
7/31Wed
2 stopsAmerican Airlines
11h 15mMYR-TYS
$260

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Last minute flights from Myrtle Beach to Knoxville

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Myrtle Beach to Knoxville that are departing in the next 10 days.
6/15Sat
multi-stopAmerican Airlines
3h 35mMYR-TYS
6/20Thu
multi-stopAmerican Airlines
3h 15mTYS-MYR
$305
6/13Thu
multi-stopAmerican Airlines
3h 35mMYR-TYS
6/15Sat
multi-stopAmerican Airlines
3h 49mTYS-MYR
$314
6/13Thu
multi-stop
8h 10mMYR-TYS
6/15Sat
multi-stop
10h 46mTYS-MYR
$426
6/14Fri
multi-stop
15h 43mMYR-TYS
6/16Sun
multi-stop
16h 36mTYS-MYR
$429
6/14Fri
multi-stop
18h 46mMYR-TYS
6/16Sun
multi-stop
16h 36mTYS-MYR
$449
6/15Sat
multi-stopAmerican Airlines
3h 02mMYR-TYS
6/21Fri
multi-stopAmerican Airlines
3h 49mTYS-MYR
$468
6/14Fri
multi-stop
15h 43mMYR-TYS
6/16Sun
multi-stop
7h 12mTYS-MYR
$530
6/16Sun
multi-stopAmerican Airlines
5h 29mMYR-TYS
6/21Fri
multi-stopAmerican Airlines
4h 15mTYS-MYR
$868
6/15Sat
multi-stopUnited Airlines
7h 46mMYR-TYS
6/20Thu
multi-stopUnited Airlines
5h 29mTYS-MYR
$893
6/15Sat
multi-stopUnited Airlines
19h 24mMYR-TYS
6/21Fri
multi-stopUnited Airlines
5h 29mTYS-MYR
$1,338

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Myrtle Beach - Knoxville Flights

Departure:

Myrtle Beach (MYR)United States

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - Myrtle Beach

Cabin classes: