Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (68% of total searches to Lesbos). The next most popular destinations are Míthymna (18%) and Skala Eresou (9%). Searches for hotels in Petra (5%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as $34 (Mytilene) in the last 3 days. The average price is $103.